I'll put it to you this way: this comic is among my most valuable possessions. It's dear enough to me that I found a copy on eBay to give to my wedding director as a thank you.
"Hold Me," issue #27 of Hellblazer.
The man does poignant very, very well.
EDIT: And I just found out they're making a live action version of The Last Unicorn, supposedly scheduled for release in 2006.